张运海

张运海,男,理学博士,安徽农业大学教授、博士生导师、动物科技学院副院长,主要从事动物繁殖与生物技术应用基础研究;安徽省现代牛羊产业技术体系副首席专家兼功能室主任,安徽省学术与技术带头人后备人选,安徽青年科技奖获得者,兼任安徽省细胞生物学学会理事、安徽省畜牧兽医学会理事、中国畜牧兽医学会动物繁殖学分会理事;主持或参与完成国家级和省部级以上科研项目20余项;主持在研省级以上各类科研项目5项;我国首例体细胞克隆猪、国际首例手工克隆猪主创人之一。近5年来,公开发表研究论文200多篇,其中SCI论文100多篇,第一或通讯作者SCI论文30多篇,被引用频次900多次,H指数18;取得授权国家发明专利10余项。获国家科技进步奖二等奖1项、“神农中华农业科技奖”一等奖1项、安徽省科技一等奖1项、安徽省科技三等奖2项、安徽省教学成果二等奖1项;参与取得省级科技成果10多项。主持或参与完成教研项目3项,主持在研校级教研项目1项,参与国家级教研项目3项;指导校级大学生创新基金课题20余项(国家级3项,省级2项)。

主要研究兴趣
(1)家畜体细胞核移植(克隆)与转基因
(2)体细胞重编程技术应用研究
(3)体细胞重编程机制研究
(4)牛羊高效繁殖技术研发、示范与推广

代表性文章
Dynamic reprogramming of 5-hydroxymethylcytosine during early porcine embryogenesis.Theriogenology.2014(2):496-508
https://doi.org/10.1016/j.theriogenology.2013.10.025

2016-2018年主要学术文章列表
2018年
(1)Cao, Z.B.#, Gao, D., Xu, T.T., Tong, X., Wang, Y.Q., Li, Y.S., Fang, F.G., Ding, J.P., Zhang, X.R., Zhang, Y.H., 2018. Human exhaled air can efficiently support in vitro maturation of porcine oocytes and subsequent early embryonic development. Anim. Reprod. 15, 29-38.(2)Li YS#, Liu X#, Chen Z, Song DD, Yang J, Zuo XY, Cao ZB, Liu Y, Zhang YH.(2018)Effect of Follistatin on Pre-Implantational Development of Pig Parthenogenetic Embryos. Animal Science Journal, 89(2):316-327.(3)Li X#, Zhang PF#, Jiang SS, Ding B, Zuo XY, Li YS, Cao ZB, Zhang YH.(2018)Aging adult porcine fibroblasts can support nuclear transfer and transcription factor-mediated reprogramming.Animal Science Journal, 89(2):289-297.
2017年
(1)Cao ZB#,Wu RH#,Gao D,Xu TT,Luo L,Li YS, Han JY,Zhang YH.(2017).Maternal histone acetyltransferase KAT8 is required for porcine preimplantation embryo development.Oncotarget,, 8 (52) :90250-90261.(2)Chen Z.#, Zuo X.#, Li H., Hong RY., Ding B., Liu CX., Gao D., Shang H., Cao ZB., Huang WP., Zhang XR., Zhang YH.(2017) Effects of melatonin on maturation, histone acetylation, autophagy of porcine oocytes and subsequent embryonic development. Animal science journal, DOI:10.1111/asj.12779
(3)Ding B#, Cao ZB#, Hong RY, Li H, Zuo X, Luo L, Li YS, Huang WP, Li WY, Zhang K, Zhang YH.(2017) WDR5 in porcine preimplantation embryos: expression, regulation of epigenetic modifications and requirement for early development. Biology of Reproduction, doi: 10.1093/biolre/iox020
(4)Gao XX.#, Ye J., Yang C., Zhang KF., Li XM., Luo L., Ding JP., Li YS., Cao HG., Ling YH., Zhang XR., Liu Y., Fang FG., Zhang YH..(2017) Screening and evaluating of long noncoding RNAs in the puberty of goats. Bmc Genomics 18. doi:10.1186/s12864-017-3578-9
(5)Cao ZB.#, Hong RY.#, Ding B., Zuo XY., Li H., Ding JP., Li YS., Huang WP., Zhang YH.(2017) TSA and BIX-01294 Induced Normal DNA and Histone Methylation and Increased Protein Expression in Porcine Somatic Cell Nuclear Transfer Embryos. Plos One 12: e0169092. doi:10.1371/journal.pone.0169092(6)Wang ZF#, Liu CX#, Hong RY, Yang J, Li H, Li YS, Cao HG, Zhang YH, Cao ZB. (2017) Effect of histone deacetylase inhibitor romidepsin on the in vitro growth of foetal fibroblast cells and early development of porcinecloned embryos, Italian Journal of Animal Science, DOI: 10.1080/1828051X.2016.1277963
(7)Tao J#, Zhang Y#, Zuo XY, Hong RY, Li H, Liu X, Huang WP, Cao ZB, Zhang YH. (2017) DOT1L inhibitor improves early development of porcine somatic cell nuclear transfer embryos. PLoS ONE 12(6): e0179436. https://doi.org/10.1371/journal.pone.01794362016年(1)Yao Q, Chen L, Liang Y, Sui L, Guo L, Zhou J, Fan K, Jing J, Zhang YH, Yao B. (2016) Blastomere removal from cleavage-stage mouse embryos alters placental function, which is associated with placental oxidative stress and inflammation. Scientific Reports, 6:25023.(2)Ling YH#, Guo XF, Chen T, Ding JP, Ma YH, Chu MX, Di R, Zhang YH, Zhang XR. (2016) Characterization and analysis of differentially expressed microRNAs in hircine ovaries during the follicular and luteal phases. Animal Reproduction Science,166:47-57(3)Yang C#, Ye J#, Li X, Gao XX, Zhang KF, Luo L, Ding JP, Zhang YH, Li YS, Cao HG, Ling YH, Zhang XR, Liu Y, Fang FG. (2016) DNA Methylation Patterns in the Hypothalamus of Female Pubertal Goats. PLoS ONE 11(10): e0165327. https://doi.org/10.1371/journal.pone.0165327

参考阅读
https://www.researchgate.net/profile/Yunhai_Zhang3/contributions
https://jsxx.ahau.edu.cn/jsxx_show.asp?ID=20051500

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