瞿昆(中国科技大学)

成果报道
2019年底,研发团队先后于Genome Biology、Genome Research杂发表两项重要非编码RNA研究成果,为深入解析非编码RNA生物学意义,探索其对基因表达的调控机制及与人类健康的密切关系带来了新的进展。

个人简介
瞿昆,男,博士,中国科学技术大学生命科学学院教授、博士生导师。长期从事生物信息学,系统生物学,基因组学和遗传学等领域的研究。在New England Journal of Medicine, Nature, Nature Methods, Nature Biotechnology, Cell, Cell Stem Cell, Molecular Cell, Developmental Cell, Cell Systems, Genome Research, Genes and Development等国际学术期刊上共发表论文38篇,5年内Google学术引用超过1800次,总影响因子超过400,H-index 19。目前担任PNAS,Nature Protocol等杂志的审稿人。

科研项目
单细胞组学研究反复流产患者脱膜免疫微环境紊乱机制(2020年1月-2023年12月),国家自然基金委面上项目科研项目;
T细胞淋巴瘤的表观遗传调控(2018-2021年);
包硅镍钴合金纳米颗粒通过核磁共振成像及抑制炎症小体激活实现肿瘤诊疗一体(2019-2022年)

学习经历
1999-2004年中国科学技术大学化学物理系,获学士学位
2004-2010年美国印第安纳大学化学系,获物理化学博士学位

工作经历
2009-2010年美国希望之城,贝克曼癌症研究中心,生物信息学专家
2010-2016年美国斯坦福大学医学院,生物信息高级研究员,中心主任
2016年至今中国科学技术大学生命科学学院,教授,博士生导师

荣誉记录
ORISE Fellowship 2007

科研方向
个性化医疗,肿瘤的个性化调控机制
生物大数据分析,云计算基础上的生物信息系统分析软件的开发和应用
转录因子,非编码RNA 和表观遗传修饰对基因表达的调控作用和机制

学术文章(*共同一作)

  • H. Xie, W. Zhang, M. Zhang, T. Akhtar, Y. Li, W. Yi, X. Sun, Z. Zuo, M. Wei, X. Fang, Z. Yao, K. Dong, S. Zhong, Q. Liu, Y. Shen, Q. Wu, X. Wang, H. Zhao, J. Bao, K. Qu#, T. Xue# “Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids”. Science Advances ,FEB. 2020.
  • Cai, Auke BC Otten, B. Cheng, Mitsuhiro A. Ishii, W. Zhang, B. Huang, K. Qu#, Bryan K. Sun# “A genome-wide long noncoding RNA CRISPRi screen identifies PRANCR as a novel regulator of epidermal homeostasis”. Genome Research ,JAN. 2020.
  • Fang J, Ma Q, Chu C, Huang B, Li L, Cai P, Batista PJ, Tolentino KEM, Xu J, Li R, Du P, Qu K#, Chang HY: Functional classification of chromatin associated lncRNAs via histone modification specific PIRCh-seq analysis. Genome Biology ,DEC. 20, 2019.
  • Z. Zuo, Y. Jin, W. Zhang, Y. Lu, B. Li & K. Qu# “ATAC-pipe: general analysis of genome-wide chromatin accessibility”, Briefings in Bioinformatics, 2018.
  • X. Bao, Z. Siprashvili, B. Zarnegar, R. Shenoy, E. Rios, N. Nady, K. Qu, A. Mah, D. Webster, A. Rubin, G. Wozniak, S. Tao, J. Wysocka, P. Khavari “CSNK1a1 regulates PRMT1 to maintain the progenitor state in self-renewing somatic tissue”, Developmental Cell, 47, 227–239, 2017.
  • W. Pan, S. Zhu, K. Qu, K. Meeth, J. Cheng, K. He, H. Ma, Y. Liao, X. Wen, C. Roden, Z. Tobiasova, Z. Wei, J. Zhao, J. Liu, J. Zheng, B. Guo, S. Khan, M. Bosenberg, R. Flavell, J. Lu “The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression”, Immunity, 47, 284–297, 2017.
  • K. Qu, L. Zaba, A. Satpathy, P. Giresi, R. Li, Y. Jin, R. Armstrong, C. Jin, N. Schmitt, Z. Rahbar, H. Ueno, W. Greenleaf, Y. Kim, H. Chang “Chromatin accessibility landscape of cutaneous T cell lymphoma and dynamic response to HDAC inhibitors”, Cancer Cell, 32, 1-15, 2017.
  • G. Wu, M. Yuan, S. Shen, X. Ma, J. Fang, L. Zhu, L. Sun, Z. Liu, X. He, D. Huang, T. Li, C. Li, J. Wu, X. Hu, Z. Li, L. Song, K. Qu#, H. Zhang & P. Gao “Menin enhances c-Myc-mediated transcription to promote cancer progression” Nature Communications, 8, 15278, 2017.
  • C. Jin , K. Qu “Application of bioinformatics techniques in revealing the mechanisms of epigenetic regulation“ SCIENTIA SINICA Vitae 47(1), 116-124 , 2017.
  • K. Qu, S. Garamszegi, F. Wu*, et al, J. Mesirov “Integrative genomic analysis by interoperation of bioinformatics tools in GenomeSpace”, Nature Methods, 2016, Jan 18. doi: 10.1038/nmeth.3732.
  • K. Qu, L. Zaba, P. Giresi, et al, H. Chang “Individuality and dynamics of personal regulomes in human T cells”, Cell Systems, 1:51-61, 2015 (Previewed in Cell System)
  • Y. Wan, K. Qu, Q. Zhang, R. Flynn, O. Manor, Z. Ouyang, J. Zhang, R. Spitale, M. Snyder, E. Segal and H. Chang “Landscape and variation of RNA secondary structure across the human transcriptome” Nature, 505:706-9, 2014 (Highlighted in Nature News & Views)
  • V. Lopez-Pajares, K. Qu, et al, P. Khavari “A LncRNA-MAF/MAFB Transcription Factor Network Regulates Epidermal Differentiation”, Developmental Cell, 32(6), 693-706, 2015 (Cover Article, Previewed in Developmental Cell)
  • C. Benitez, K. Qu, et al, S. Kim “An Integrated Cell Purification and Genomics Strategy Reveals Multiple Regulators of Pancreas Development”, PLoS Genetics, Oct. 16, 2014
  • J. Quinn, I. Ilik, K. Qu, P. Georgiev, et al., H. Chang “Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification”, Nature Biotechnology, 32:933-940, 2014
  • P. Batista, B. Molinie, J. Wang*, K. Qu, et al., H. Chang “m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells”, Cell Stem Cell, 15(6), 707-719, 2014
  • O. Wapinski, T. Vierbuchen, K. Qu, et al., H. Chang, and M. Wernig “Hierarchical mechanisms for transcription factor-mediated reprogramming of fibroblasts to neurons” Cell, 155(3), 2013
  • Y. Wan, K. Qu, Z. Ouyang, and H. Chang “Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing” Nature Protocols, 8(5):849-69, 2013
  • N. Rapicavoli, K. Qu, et al., H. Chang “A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics” eLife, July 23, 2013
  • X. Bao, J. Tang, V. Lopaz-Pajares, S. Tao, K. Qu, G. Crabtree, P. Khavari “ACTL6a Enforces the Epidermal Progenitor State by Suppressing SWI/SNF-Dependent Induction of KLF4” Cell Stem Cell, 12(2):193-203, 2013
  • M. Kretz, D. Webster, C. Chu, Z. Siprashvili, A. Zehnder, K. Qu, et al., H. Chang, and P. Khavari “Control of Somatic Tissue Differentiation by the Long Non-Coding RNA TINCR” Nature, 493(7431):231-5, 2013 (Faculty 1000)
  • R. Flockhart, D. Webster, K. Qu, et al., P. Khavari “BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration” Genome Research, 22(6):1006-14, 2012 (Highlighted in Nature Reviews Cancer)
  • Y. Wan, K. Qu, Z. Ouyang, et al., E. Segal, H. Chang. “Genome-wide measurement of RNA folding energies” Molecular Cell, 48:1-13, 2012 (Faculty 1000)
  • A. Bhaduri, K. Qu, et al., and P. Khavari. “Rapid Identification of Nonhuman Sequencing in High Throughput Sequencing Data Sets” Bioinformatics, 28(8):1174-5, 2012 (Faculty 1000)
  • N. Gomez-Ospina, A. Chang, K. Qu, A. Oro. “Translocation Affecting Sonic Hedgehog Gene associated with Basal Cell Carcinomas” The New England Journal of Medicine, 366:2233-2234, 2012
  • C. Chu, K. Qu, F. Zhong, S. Artandi, H. Chang. “Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions” Molecular Cell, 44(4), 667-678, 2011 (Cover Article, Highlighted in Nature Reviews Genetics and Nature Methods, Faculty 1000)
  • S. Marro, Z. Pang, N. Yang, M. Tsai, K. Qu, et al., M. Wernig “Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons” Cell Stem Cell, 9(4) 374-382, 2011 (Cover Article, Faculty 1000, and Highlighted in Nature Biotechnology)
  • K. Qu, A. Yesnik, P. Ortoleva. “Alternative splicing regulatory network reconstruction from exon array data” Journal of Theoretical Biology, 263: 471-480, 2010
  • K. Qu, P. Ortoleva, “Understanding stem cell differentiation through self-organization” Journal of Theoretical Biology, 250(4): 606-20, 2008
  • K. Qu, A. Haidar, J. Fan, L. Ensman, K. Tuncay, M. Jolly, P. Ortoleva. “Cancer Onset and Progression: A Genome-Wide, Nonlinear Dynamical Systems Perspective on Onconetworks”. Journal of Theoretical Biology, 246: 234-244, 2007

参考阅读
Google学术页面:http://scholar.google.com/citations?hl=en&user=2CdOi4EAAAAJ
实验室网页:http://qulab.ustc.edu.cn/
ResearcherID: http://www.researcherid.com/rid/G-3359-2012
http://www.hfnl.ustc.edu.cn/detail?id=11368
https://biox.ustc.edu.cn/2016/0221/c699a11097/page.htm

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